Uncontrolled Diabetes with Underlying Structural Changes in the Atrioventricular Node

Diabetic cardiomyopathy, characterized by diabetes mellitus (DM) -induced cardiac muscular abnormalities, is a strong inducer of impaired contraction and arrhythmia. Atrioventricular block, serious type arrhythmia resulting from interruption impulse conduction via the atrioventricular node (AVN), frequently occurs among diabetic patients. However, details structural changes in AVN DM remain poorly explained. Here, this study defined effects on morphological remodeling male Sprague Dawley rats induced intraperitoneal injection streptozotocin (60 mg/kg body weight). At 24 weeks, pathological were assessed light microscopy (LM) transmission electron (TEM). Under LM, became less compact mass exhibited intracellular vacuolation. The nodal cells more varied sizes with absence or shrinkage nuclei clear cytoplasm compared to control. collagen content significantly increased relation presence myofibroblasts. Consistent TEM images revealed several signs cell damage, such as mitochondrial changes, deterioration organelles, gap junction internalization, separation. Furthermore, innervation, evidenced damaged Schwann axons, also found. These results indicated alterations important components during condition, which may lead impairment electrical conduction, causing abnormal functions